Abstract: The management of hilar cholangiocarcinoma was challenging to the surgeons due to difficult operations and low resection rate. Recently, a new mode of multidisciplinary team (MDT) is applied to the diagnosis and treatment of hilar cholangiocarcinoma, which leads to significant changes and development of the diagnosis and treatment for hilar cholangiocarcinoma. In this article, the authors first introduced the recent application of MDT treatment for hilar cholangiocarcinoma on diagnostic methods, staging systems, evaluation for resectability, radical resection, application of liver transplantation and other systematic therapies. Considering the complexity of hilar cholangiocarcinoma, a surgerycentered MDT for hilar cholangiocarcinoma is important and should be promoted.