Abstract: The incidence of chronic pancreatitis (CP) is increasing recently. The major risk factor of CP is alcohol drinking. Abdominal pain and insufficiency of exocrine and endocrine function are the common clinical manifestations. The primary diagnosis is based on the clinical features and imaging findings, and contrastenhanced CT is the method of choice. The results of biopsy could present the definite diagnosis, but are not recommended for routine application. Conservative treatments include alcohol abstinence, alteration of diet, pancreatic enzymes replacement, blood glucose control and analgesia. Glucocorticoids are the first line of therapy for autoimmune pancreatitis. Endoscopic intervention provides new methods for management of CP, however, the longterm outcome is inferior to that of surgery. Surgical therapy depends on individualization, including pancreatic duct drainage (Partington procedure), different pancreatectomies procedures, such as Whipple′s procedure, pyloruspreserving pancreaticoduodenectomy (PPPD), distal pancreatectomy, middle segmental pancreatectomy and total pancreatectomy. A combined procedure of drainage and local resection of the inflamed tissue could be an effective treatment, including Beger procedure and its modified methods, Frey  procedure,Izbicki procedure and Berne procedure. The postoperative regular followup is recommended.