Abstract: Peliosis hepatis is a rare benign hepatic vascular disease. There is the lack of specific clinical features and preoperative diagnosis. A patient with intermittent liver area pain was admitted to the Third Central Hospital of Tianjin in April 2014. The patient with spaceoccupying lessions of the right lobe of liver was preliminarily diagnosed as with hepatocellular tumor or vasogenic tumor by computed tomography and B ultrasound examinations and then received liver resection combined with cholecystectomy. The result of postoperative pathological examination confirmed peliosis hepatis with adenomatous hyperplasia of liver cells. The patient was followed up till October 20, 2014 without recurrence.