Abstract: Metabolic abnormality is correlated with the incidence of colorectal cancer. Metabolic syndrome is consisting of abdominal obesity, dyslipidemia, high blood pressure, sugar metabolic abnormality, and all of these factors are associated with colorectal cancer. Abdominal obesity and sugar metabolic abnormality may be the primary factors causing rectal cancer. Visceral fat is physiologically more active than subcutaneous fat. Visceral fat can produce and secret hormones and cytokines, which are involved in inflammation and metabolism, therefore the amount of visceral fat may directly or indirectly related to the occurrence of colorectal cancer. Obesity acts as a risk factor for colorectal cancer by several mechanisms, including high blood insulin, insulin like growth factor, and the change of the adipose cytokines concentrations. Metabolic biomarkers may not only provide clues of colorectal carcinogenesis from the point of view of etiology, but also can help to explore new obesity phenotypes that is relevant to incidence risk of colorectal cancer.