Abstract: In order to investigate the clinical value of multi slice computed tomography (MSCT) in the diagnosis colonic neoplasms, the clinical data of 57 patients who were confirmed as with colonic neoplasms were admitted to the Wuxi No.2 People's Hospital from June 2013 to June 2014. Patients received plain and enhanced scan of MSCT, multiplannar reconstruction (MPR), sliding thin slab maximum intensity projection (STS MIP) and curved planar reformation (CPR), and the results of these examinations were compared with the postoperative TNM stage. Of the 57 patients, tumors located at the cecum in 1 patient, ascending colon in 23 patients, hepatic region of the colon in 9 patients, transverse colon in 11 patients, splenic region of the colon in 1 patient, descending colon in 3 patients and sigmoid colon in 9 patients. The results of the CT examination were in accordance with the results of exploratory laparotomy. The wall of the intestine was irregular ring like thickened in 57 patients. The thickening of the intestine ranged between 0.6 3.2 cm, and patients had intestinal stricture in different degrees. Sixteen patients had gas fluid level and dilatation of the intestine and were presented with intestinal obstruction signs. Forty two patients had nodular or mass shadow in soft tissues, and the nodules or mass protruded into the intestinal cavity or outside of the intestinal cavity, and resulting in intestinal stricture. The junction of the mass and the adjacent intestinal wall was blurred or clear, and the thickness of the intestinal walls was normal. Carcinomatous ulcer was observed in 20 patients. The shape of the ulcer was crateriform. The serosa and (or) adjacent organs were invaded by the tumors in 47 patients. Twenty seven patients had lymph node metastasis, including 6 had distal metastasis, 4 had hepatic metastasis and 2 had pulmonary metastasis. The sensitivity and accuracy of the preoperative CT examination for T stage were 100.0%(57/57) and 77.2%(44/57), respectively. The sensitivity, specificity and accuracy of the CT examination for N stage were 67.9%(19/28), 72.4%(21/29) and 70.2%(40/57), respectively. The sensitivity, specificity and accuracy of the CT examination for M stage were 100.0%(6/6), 100.0%(51/51) and 100.0%(57/57), res pectively. The results of CT examination for TNM stage were well correlated with the pathological examination for TNM stage (κ=0.592, 0.514, 1.000, P<0.05). MSCT scanning and post processing technique are of important clinical value in depicting tumor location, size and morphology, delineating tumor extension, revealing lymph nodes and metastases, and confirming preoperative tumor TNM stage in patients with colonic neoplasms.