Abstract: Duodenum and bile duct preserving pancrea tic head resection is rarely carried out in China due to its complexity. From September 2013 to May 2014, 5 patients (1 with mass forming pancreatitis of the head of the pancreas, 2 with mucinous cystadenoma of the pancreatic duct combined with focal cancerous, 2 with chronic pancreatitis and pancreatic duct stones) received duodenum and bile duct preserving pancreatic head resection at the Zhangzhou Zhengxing Hospital. The lesions of the 5 patients were resected by the Takada method and then the pancreatic duct was reconstructed in situ. One patient received T tube drainage of the bile duct. The operation time was 210 330 minutes, and the mean volume of intraoperative blood loss was 300 mL (range, 100 500 mL). The stones of 2 patients were antler shaped, and the other 3 patients were with tumor. No patients died intraoperatively. One patient was complicated by pancreatic leakage and 1 by bile leakage after the operation, respectively, and they were cured by 〖HJ*4〗non surgical duct stricture, chronic indigestion and tumor recurrence occurred. The Takada method is safe and effective for the treatment of mass forming pancreatitis of the head of the pancreas, benign lesions of the head of the pancreas and low grade malignant tumor of the head of the pancreas.