Abstract: The significance of perioperative management has been recognized as the mature of the technique of liver resection. Mounted results of researches show that excessive inflammatory response after liver resection is an important factor causing different complications, and it even can threaten the life of the patients. Therefore, based on thorough discussions of experts from the fields of hepatobiliary surgery, anesthesiology and intensive care unit, the update of the latest research and the experience of the experts, the Multiple disciplinary consensus on the management of excessive inflammatory response in the perioperative period of hepatectomy (2014 edition) was composed. The content of the consensus included the cause, damage, method of evaluation and management principle of the excessive inflammatory response in the perioperative period of hepatectomy, with the aim to reduce the postoperative complications after hepatectomy and promote the recovery of the patients.