Abstract: Some locally advanced tumors involving multiple abdominal organs without distal metastasis may cause digestive tract obstruction. Some of these patients can achieve long term survival after R0 resection, others can obtain digestive tract obstruction relief, pain anesis and survival prolongation after R1 resection combined with postoperative comprehensive treatment. In this review, the efficacy of complex pancreaticoduodenectomy combined with organs resection was introduced based on reviewing the literatures. After the surgery, some patients achieved R0 resection and long term survival, and the quality of life was significantly improved in some patients.