Abstract: Crohn′s disease is a relapsing systemic inflammatory disease mainly affecting the gastrointestinal tract. Recently, the incidence and prevalence of Crohn′s disease is increasing dramatically in Asia, and colorectal cancer is one of the most fatal complications of Crohn′s disease. A thorough understanding of the carcinogenesis of Crohn′s disease and enhance the surveillance of colorectal cancer among Crohn′s disease is therefore of significant importance to reduce the mortality. In this review, the tendency and molecular mechanism of carcinogenesis of Crohn′s disease were discussed, and the present research on the prevention against colorectal cancer in patients with Crohn′s disease was introduced.