Abstract: Acute obstructive suppurative cholangitis (AOSC) is one of the most serious acute abdomen. The incidence of abdominal infection is significantly improved when patients were complicated with AOSC and diabetes mellitus, and then bile leakage, intestinal fistula and even death were induced by abdominal infection. The management of abdominal infection is very important for the prognosis of patients. One patient with AOSC and diabetes mellitus was admitted to the No.425 Hospital of PLA from May to July in 2013. Recurrent abdominal infection and abscess occurred after the operation due to his family members′ refusal of surgery at early period and lax control of blood glucose before and after surgery, and then bile leakage and intestinal fistula were induced. The patient underwent operation for 3 times, and was cured after receiving fasting, gastrointestinal decompression, parental nutrition, somatostatin administration and antibiotic treatment.