Abstract: Objective:To compare the shortterm efficacies of laparoscopic adjustable gastric banding (LAGB) and laparoscopic sleeve gastrectomy (LSG) in the treatment of obesity and type 2 diabetes mellitus, and to investigate the relationship between the body weight loss and the decrease of glucose of the 2 treatment methods.
Methods:The clinical data of 40 patients with obesity combined with type 2 diabetes mellitus who were admitted to the Changhai Hospital of the Second Military Medical University from January 2010 to December 2011 were retrospectively analyzed. There were 14 patients treated by LAGB (LAGB group) and 26 by LSG (LSG group). The body weight loss and the decrease of glucose at postoperative year 1 of the 2 groups were compared. The differences in the body weight and glucose before and after operation within groups were compared using the paired t test, and the differences in the body weight and glucose between the 2 groups were compared using the multiple analysis of variance. The correlation between the body weight loss and the decrease of glucose was analyzed using the linear regression analysis.
Results:Laparoscopic surgery was successfully done without conversion to open surgery or intraoperative complications. The operation time and volume of blood loss were (69±16)minutes and (31±14)mL in the LAGB group, (120±15)minutes and (148±48)mL in the LSG group. Complications including postoperative malnutrition, electrolyte disturbance, delayed gastric emptying, bleeding, anastomotic leakage did not occurr in the 2 groups. Two patients were complicated with abdominal incision fat liquefaction, and were cured by symptomatic treatment. (1) The body weight, body mass index (BMI) and waistline had a decrease trend. The body weight, BMI and waistline in the LAGB group were decreased from (117±28)kg, (40±8)kg/m2 and (118±15)cm before operation to (94±28)kg, (33±8)kg/m2 and (92±15)cm at postoperative week 48. The body weight, BMI and waistline in the LSG group were decreased from (119±25)kg, (42±6)kg/m2 and (123±14)cm before operation to (74±16)kg, (26±4)kg/m2 and (86±13)cm at postoperative week 48. The EWL had an increase trend in the 2 groups. The EWL in the LAGB group was increased from 7%±2% at postoperative week 1 to 53%±24% at postoperative week 48, and the EWL in the LSG group was increased from 11%±4% at postoperative week 1 to 90%±20% at postoperative week 48. There were significant differences in the changes of body weight, BMI, waistline and EWL between the 2 groups (F=60.660, 74.490, 57.650, 90.020, P<0.05). (2) The levels of glycosylated hemoglobin, fasting glucose, fasting insulin, HOMAIR, triglyceride, total cholesterol, lowdensity lipoprotein and high density lipoprotein in the LAGB group were decreased from 8.1%±0.8%, (8.4±0.6)mmol/L, (21±8)μmol/L, 7.9±2.9, (1.68±0.50)mmol/L, (6.0±1.1)mmol/L (4.1±0.8)mmol/L, (1.09±0.15)mmol/L to 6.4%±0.8%, (6.3±0.3)mmol/L, (10±3)μmol/L, 2.7±0.9, (1.04±0.09)mmol/L, (4.3±0.8)mmol/L, (2.3±0.4) mmol/L, (1.22±0.09)mmol/L at postoperative week 48; the levels of glycosylated hemoglobin, fasting glucose, fasting insulin, HOMAIR, triglyceride, total cholesterol, lowdensity lipoprotein and high density lipoprotein in the LSG group were changed from 7.9%±1.0%, (9.0±1.0)mmol/L, (21±9)μmol/L, 8.5±3.5, (2.09±0.70)mmol/L, (6.0±1.2)mmol/L, (3.9±1.1)mmol/L, (1.06±0.21)mmol/L before operation to 5.1%±0.8%, (5.2±0.4)mmol/L, (4±1)μmol/L, 0.9±0.2, (1.22±0.17)mmol/L, (4.2±0.8)mmol/L, (2.3±0.6)mmol/L, (1.30±0.13)mmol/L at postoperative week 48. There was a decrease trend of the glycosylated hemoglobin, fasting glucose, fasting insulin, HOMAIR, trigluceride, total cholesterol and low density lipoprotein and a increase trend of the high density lipoprotein in the 2 groups. There were significant differences in the levels of glycosylated hemoglobin, fasting glucose, fasting insulin, HOMAIR, triglyceride, total cholesterol, lowdensity lipoprotein and high density lipoprotein between the 2 groups (F=57.650, 74.270, 36.750, 42.960, 10.870, 30.650, 32.560, 11.490, P<0.05). The levels of glucose of the LAGB group at postoperative month 1 and 3 were influenced by BMI (b=0.543, 0.753, P<0.05), while the levels of glucose of the LAGB group did not be influenced by BMI at postoperative month 6 and year 1 (b=0.130, 0.222, P>0.05). The levels of glucose of the LSG group did not be influenced by BMI at postoperative month 1, 3, 6 and year 1 (b=0.185, 0.035, 0.212, 0.126, P>0.05).
Conclusion:The efficacy of LSG is superior to LAGB for the treatment of obesity combined with type 2 diabetes mellitus. The efficacy of LAGB is correlated with the change of body weight, while the efficacy of LSG does not correlated with the change of body weight.