Abstract: Inadequate volume of the remnant liver after hepatectomy for giant liver cancer is the main cause of hepatic failure. Blocking the portal vein and hepatic artery of one side, degrade the stage of the tumor, and increase the contralateral postoperative residual liver volume became one of the methods for the treatment of giant liver cancer. A patient with giant right liver cancer was admitted to the First Affiliated Hospital of Xiamen University on March 22, 2013. Because of the inadequate volume of remnant liver, the portal vein and hepatic vein were selectively ligated, and then followed by hepatectomy. The size of the tumor was decreased after ligation of the portal vein and hepatic artery, and the volume of the remnant left liver was increased from 488 mL to 689 mL at the first months after the operation. The duration between the first and second surgeries was 33 days. No severe complications were detected after the surgeries. The patient was followed up for 2 months, tumor recurrence did not detected in the remnant left liver, and the level of alpha fetoprotein was decreased from preoperative 425 mg/L to post operative 26×10 -3 mg/L. Selective ligation of portal vein and hepatic artery combined with sequential hepatectomy might be an effective treatment method for giant liver cancer.