Abstract: The progress of liver surgery is characterized by precision, minimal invasion and effectiveness in the 21st century. Establishment of painless liver surgery ward and implementation of pain management in the perioperative period are not only the central content of enhanced recovery after surgery, but also one of the core connotation in precision liver surgery research. Conducting training programs for medical staffs, emphasizing health education of pain, selecting the reasonable pain assessment strategy, combination of preemptive analgesia and multimodal analgesia in the perioperative period and paying attention to individualized analgesia are important contents of construction of painless liver surgery ward. To carry out multi centre clinical study energetically, explore clinical pathway for the construction of painless ward and perioperative analgesic model are the development orientation for the construction of painless liver surgery ward.