Abstract: Intrahepatic bile duct stones located at the upper part of the hepatic duct. The percentage of intrahepatic biliary cholesterol calculus is increasing in recent years, and the incidence of this type of bile duct stones is free from infection or obstruction. The formation of intrahepatic bile duct stones might not only related to the micro environment changes in the biliary tract, but also related to the changes of metabolic function of hepatocytes or cholangiocytes. In this article, the mechanism of biliary hydrodynamics on the formation of intrahepatic bile duct stones was reviewed.