Abstract: Objective:To compare the perioperative efficacy berween laparoscopic and open gastrectomy for the treatment of advanced gastric cancer.
Methods:Literatures on the comparison of the efficacy between laparoscopic and open gastrectomy were searched in the PubMed, EMBASE, the Cochrane Library, CNKI and CMCC. Articles were selected according to the inclusion criteria, and data were extracted from these trials by 2 reviewers independently and analyzed by Review Manager 5.0 software. The heterogeneity of the literatures was analyzed using the I 2 test. Data were integrated by fixed or random effect model. The count data were presented by odds ratio ( OR ) and 95% confidence interval (95% CI ).
Results:Twelve literatures were retrieved, including 1 published in Chinese and 11 in English, 1 randomized controlled study and 11 retrospective non randomized controlled studies. A total of 2 079 cases of advanced gastric cancer were included in this study, including 882 in the laparoscopic gastrectomy group and 1 197 in the open gastrectomy group. There were significant differences in the operation time, intraoperative blood loss, time to first flatus, time to first diet and duration of hospital stay between the 2 groups ( WMD=41.33,-106.00,-0.55,-0.76,-2.62, 95%CI: 25.44 -1.08, P >0.05).
Conclusion:Laparoscopic gastrectomy can be safely performed for the treatment of advanced gastric cancer, and it brings benefits to patients in perioperative period than open gastrectomy.