Abstract: Liver has great ability in regeneration, and liver regeneration is closely related to the prognosis of patients who received liver surgeries. The mechanisms of liver regeneration include biochemical theory and hemodynamic theory. Portal perfusion with moderate pressure is an important factor for starting liver regeneration. Hepatic artery buffer response, fluid shear stress and gasotransmitter play important roles in the liver regeneration. Learning the mechanisms of hemodynamic signal is of great importance for the treatment of liver diseases.