Hilar cholangiocarcinoma (HCC) is a rare tumor with a poor prognosis. With the development of high definition imaging technology, improvement of surgical instruments, optimization of perioperative surgical strategies and accumulation of surgical experiences, the radical resection rate of HCC is significantly improved. Operation is the main method of treatment for HCC, and radical resection is important for a long-term survival of HCC patients. The clinical data of 66 patients with HCC who were admitted to the Beijing Youan Hospital from April 2004 to April 2012 were retrospectively analyzed. The key points in surgical procedure and prognosis of patients were investigated.