Abstract: Comprehensive treatment dominated by surgery is the mainstay in the treatment of hepatic cancer, and hepatectomy is still the most effective treatment method. Bile duct reconstruction after hepatectomy is still the difficult point for the treatment of hepatic cancer complicated by bile duct invasion. A 45yearold patient with hepatic cancer and gallstone was admitted to the Affiliated Hospital of Guiyang Medical College, magnetic resonance cholangiopancreatography and enhanced computed tomography indicated that intrahepatic duct was dilated and tumor had invaded both left and right hepatic ducts. Cholecystectomy, mesohepatectomy, duct to duct anastomosis of left hepatic duct and common hepatic duct, duct to duct anastomosis of right hepatic duct and cystic duct were performed during the operation. The patient was cured 2 weeks after surgery.