Abstract: The Chinese protocol of diagnosis and treatment of colorectal cancer of the National Health Commission (2025 edition), based on evidence-based medicine, integrates international cutting-edge developments with Chinese clinical practice, and expands on previous versions. This article is a standardized and condensed version that retains the core diagnosis and treatment framework, high-lighting new content such as "surgical treatment of anal cancer" and "new advances in diagnosis and treatment technologies". It systematically summarizes the core points of surgery, internal medicine, radiotherapy, imaging, and pathology, making it easier for clinical doctors to quickly grasp the stan-dardized essence and promote the standardization, precision, and homogenization of colorectal cancer diagnosis and treatment.