Abstract: Intra‑abdominal infection is a common surgical disease characterized by diagnos-tic and therapeutic challenges, variable disease progression, and high morbidity and mortality rates. Such infections are often accompanied by impaired gastrointestinal function, leading to damage of the intestinal mucosal barrier, disruption of gut microbiota, and nutrient loss, all of which signifi-cantly affect patient outcomes. In recent years, advancements in diagnosis and treatment have improved patient survival rates. However, challenges such as frequent complications and prolonged hospital stays persist. In this context, medical nutritional therapy has become a crucial supportive measure, complementing pharmacological and surgical interventions. Early nutritional intervention has been shown to improve patients′ nutritional status, enhance immune function, promote postopera-tive recovery, and reduce the risk of complications and mortality. Although medical nutritional therapy plays a vital role in the comprehensive management of intra‑abdominal infections, its imple-mentation faces several challenges. These include accurately assessing nutritional requirements, selecting the optimal route of nutritional support, and preventing related complications. Based on team practice experience and reference to domestic and foreign research progress, the authors explore the optimal nutritional therapy strategies for patients with intra‑abdominal infection: personalized nutrition plans emphasize tailoring support strategies based on the patient′s specific condition, nutritional assessment, and tolerance, thereby improving nutritional outcomes and overall treat-ment efficacy.