肌肉与脂肪成分改变对肝移植预后影响的研究进展

Research progress of impact of changes in muscle and adipose tissue on outcomes after liver transplantation

  • 摘要: 肝移植是终末期肝病的有效治疗手段,但仍存在较高的手术死亡率和并发症发生率。近年来的研究发现机体成分改变,尤其是肌肉与脂肪成分的改变,是影响肝移植预后的重要因素。肌少症、肌肉脂肪变性及脂肪分布异常等与移植后的并发症增加、肿瘤复发风险升高及生存率下降密切相关。笔者综述肌肉及脂肪成分改变对肝移植预后的研究进展,分析现有研究的优势与不足,探讨基于身体成分联合预测模型的潜力与临床意义。

     

    Abstract: Liver transplantation remains the effective treatment for end‑stage liver disease, yet it is associated with considerable mortality and incidence of complications. Recent studies have shown that changes in body composition, particularly in muscle and adipose tissue, are significant factors influencing the outcomes of liver transplantation. Parameters such as sarcopenia, myostea-tosis, and abnormal fat distribution have been linked to higher rates of postoperative complications, increased tumor recurrence, and poor survival. The authors review the research progress of changes in muscle and adipose tissue on outcomes after liver transplantation, analyze the advantages and disadvantages of existing research, and explore the potential and clinical significance of the combined prediction model based on body composition.

     

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