Abstract: Abdominal infection is a common disease in the field of surgery, as well as a frequent complication following abdominal surgical procedures. It is mainly classified into uncomplicated and complicated types. Uncomplicated intra-abdominal infections is confined to the hollow viscus, whereas complicated intra-abdominal infection (cIAI) extends into the sterile areas of the peritoneal cavity, posing numerous management challenges. Therefore, the Chinese Abdominal Inten-sive Care Association of Asia Society of Emergency and Critical Care Medicine organizes experts to develop Expert consensus on the diagnosis and treatment of carbapenem-resistant organisms in complex intra-abdominal infection (2025 edition) (hereinafter referred to as the "Consensus"). The Consensus encom-passes topics such as the diagnosis and classification of intra-abdominal infection, pathogen detection, specific anti-microbial regimens against common carbapenem-resistant bacteria, multidis-ciplinary management, and preventive measures, accompanied by workflow diagrams. This Consensus aims to provide guidance for clinicians, reinforce infection prevention and control practices, promote effective anti-microbial stewardship, optimize drug usage, improve patient outcomes, and reduce the spread of infections caused by multidrug-resistant organisms.