Abstract: The liver is the main target organ for hematogenous metastases of colorectal cancer, and colorectal liver metastasis is one of the most difficult and challenging situations in the treatment of colorectal cancer. In order to improve the diagnosis and comprehensive treatment in China, the Guideline for diagnosis and comprehensive treatment of colorectal liver metastases (here in after referred to as the Guideline) has been edited and revised for many times since 2008, including the overall evaluation, personalized treatment goals and comprehensive treatments, to prevent the occurrence of liver metastases, increase the local damage rate of liver metastases, prolong long-term survival, and improve quality of life. The revised Guideline 2025 edition includes the diagnosis and follow-up, prevention, multidisciplinary team, surgery and local ablative treatment, neoadjuvant and adjuvant therapy, and comprehensive treatment. The revised guideline emphasizes precision treat-ment based on genetic molecular typing, especially recommending immune checkpoint inhibitors for mismatch repair-deficient/microsatellite instability-high patients and enriched local treatment methods, such as liver transplantation, yttrium-90 microsphere selective internal radiotherapy, etc. The revised guideline collects and summarizes the advanced experience and latest achievements in this field at home and abroad, with detailed contents and strong operability.