Abstract: Radical resection is the key for long‑term survival of pancreatic cancer patients. The positive rate of arterial margin after pancreatic cancer surgery is still high, and the peri-arterial area is a high‑risk area for local recurrence after surgery, suggesting that the arterial involvement of tumor is still a challenge in the surgical treatment of pancreatic cancer, and the corresponding surgical technical countermeasures have become a hot spot and focus in the field. The authors summarize the latest progress in research on surgical treatment for arterial involvement of pan-creatic cancer, generalize the experiences of peri‑arterial dissection in two large pancreatic cancer centers in China and Japan, and give their perspectives to the future development of pancreatic surgery in this field.