部分空肠离断在完全腹腔镜全胃切除术消化道重建中的应用价值

Application value of part-cut jejunal transection in digestive tract reconstruction of totally laparoscopic total gastrectomy

  • 摘要:
    目的 探讨部分空肠离断在完全腹腔镜全胃切除术消化道重建中的应用价值。
    方法 采用倾向评分匹配及回顾性队列研究方法。收集2018年6月至2022年9月安徽医科大学第二附属医院收治的112例行完全腹腔镜全胃切除术胃癌患者的临床病理资料;男81例,女31例;年龄为(70±8)岁。112例患者中,60例消化道重建采用部分空肠离断行Roux⁃en⁃Y吻合,设为部分离断组;52例消化道重建行传统Roux⁃en⁃Y吻合,设为传统组。观察指标:(1)倾向评分匹配情况及匹配后两组患者临床资料比较。(2)术中和术后情况。(3)随访情况。正态分布的计量资料组间比较采用独立样本t检验。计数资料组间比较采用χ2检验或Fisher确切概率法。等级资料组间比较采用非参数秩和检验。倾向评分匹配按1∶1最近邻匹配法匹配,卡钳值为0.02。
    结果 (1)倾向评分匹配情况及匹配后两组患者临床资料比较。112例患者中,90例匹配成功,部分离断组与传统组各45例。倾向评分匹配后消除匹配前体质量指数、临床TNM分期因素混杂偏倚,具有可比性。(2)术中和术后情况。倾向评分匹配后,部分离断组患者总手术时间为(217.0±15.1)min、消化道重建时间为(34.7±1.8)min;传统组患者分别为(252.6±21.9)min、(52.6±7.4)min;两组患者上述指标比较,差异均有统计学意义(t=-8.97、-15.66,P<0.05)。(3)随访情况。倾向评分匹配后90例患者均获得术后随访,随访时间为(47±15)个月。随访期间两组患者均未接受二次手术,无死亡发生。部分离断组和传统组患者分别有3例和10例发生Roux潴留综合征,两组比较,差异有统计学意义(χ2=4.41,P<0.05)。
    结论 与传统Roux⁃en⁃Y吻合比较,完全腹腔镜全胃切除术中行部分空肠离断Roux⁃en⁃Y吻合可缩短消化道重建时间,减少术后Roux潴留综合征发生。

     

    Abstract:
    Objective To explore the application value of part-cut jejunal transection in digestive tract reconstruction of totally laparoscopic total gastrectomy.
    Methods The propensity score matching and retrospective cohort study was conducted. The clinicopathological data of 112 patients with gastric cancer who underwent totally laparoscopic total gastrectomy in The Second Affiliated Hospital of Anhui Medical University from June 2018 to September 2022 were collected. There were 81 males and 31 females, aged (70±8)years. Among the 112 patients, 60 patients undergoing diges-tive tract reconstruction by Roux-en-Y anastomosis with part-cut jejunum were set as the part-cut group, and 52 patients undergoing digestive tract reconstruction by traditional Roux-en-Y anasto-mosis were set as the traditional group. Observation indicators: (1) propensity score matching status and comparison of clinical data of patients between the two groups after matching; (2) intraopera-tive and postoperative conditions; (3) follow-up. Comparison of measurement data with normal dis-tribution between groups was conducted using the independent sample t test. Comparison of count data between groups was conducted using the chi-square test or Fisher exact probability. Com-parison of ordinal data was conducted using the nonparametic rank sum test. Propensity score matching was performed using the 1∶1 nearest neighbor matching method, with the caliper value of 0.02.
    Results (1) Propensity score matching status and comparison of clinical data of patients between the two groups after matching. Of the 112 patients, 90 patients were successfully matched, with 45 cases in each of the part-cut group and the traditional group. After propensity score matching, the elimination of body mass index, clinical TNM staging confounding bias ensured comparability. (2) Intraoperative and postoperative conditions. After propensity score matching, the total operation time and digestive tract reconstruction time of patients in the part-cut group were (217.0±15.1)minutes and (34.7±1.8)minutes, versus (252.6±21.9)minutes and (52.6±7.4)minutes in the traditional group, respectively, showing significant differences in the above indicators between the two groups (t=‒8.97, ‒15.66, P<0.05). (3) Follow-up. After propensity score matching, 90 patients were followed up postoperatively for (47±15)months. During the follow-up, no patient in either group received secondary surgery, and there was no death. There were 3 cases and 10 cases of Roux stasis syndrome in the part-cut group and the traditional group, respectively, showing a significant difference between the two groups (χ2=4.41, P<0.05).
    Conclusion Compared with traditional Roux-en-Y anastomosis, the Roux-en-Y anastomosis with part-cut jejunum in totally laparoscopic total gastrectomy can signifi-cantly shorten the time for digestive tract reconstruction and reduce the incidence of postoperative Roux stasis syndrome.

     

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