直肠癌精准治疗的多维度探索
Multi-dimensional exploration of precision treatment of rectal cancer
-
摘要: 直肠癌是消化系统中较常见的恶性肿瘤之一,严重威胁人类健康。近年来,随着医学技术的飞速发展,直肠癌的治疗模式已发生变革,逐渐从传统的单一手术治疗模式向多学科综合治疗模式转变。精准治疗理念已深度融入直肠癌治疗的全过程,其不仅致力于实现肿瘤的根治,更着重关注患者术后的生命质量。在手术治疗方面,精准把握手术时机以及精准保肛,已成为提升直肠癌治疗效果的关键。目前的研究及发展趋势均致力于解决这些问题。基于患者实际情况开展个体化治疗,制订高度个体化的治疗方案,以期达到最佳治疗效果并减少不良反应。在直肠癌的治疗中,这一理念体现在对手术时机的精确判断、保肛手术的精准选择以及手术技术的精细化应用等多个环节。笔者查阅国内外相关文献,结合团队实践经验,重点阐述新辅助治疗背景下手术时机的选择、精准保肛策略以及手术技术在保肛中的重要作用。Abstract: Colorectal cancer is one of the most common malignant tumors in the digestive system, posing a serious threat to human health. In recent years, with the rapid development of medical technology, the treatment model for colorectal cancer has undergone profound changes, gradually shifting from traditional single-surgery treatment to multidisciplinary team (MDT) treat-ment. The concept of precision medicine has been deeply integrated into the entire process of colo-rectal cancer treatment, aiming not only to achieve radical tumor removal but also to focus on impro-ving postoperative quality of life of patients. In surgical treatment, accurate grasping of operative opportunity and precise preservation of anus have become key factors in enhancing the effectiveness of colorectal cancer treatment. Current research and trends are dedicated to addressing these issues. Tailored treatments based on individual patient conditions and highly personalized treatment plans aim to achieve optimal outcomes while minimizing adverse reactions. This philosophy is reflected in multiple aspects of colorectal cancer treatment, including precise judgment of surgical timing, accurate selection of sphincter-preserving surgery, and meticulous application of surgical techniques. After reviewing relevant literature both domestically and internationally, combined with practical experi-ence, the authors focus on the selection of surgical timing under neoadjuvant therapy, precise sphincter-preserving strategies, and the critical role of surgical techniques in sphincter preservation.