Abstract: Laparoscopic or robotic minimally invasive liver resection is the core treatment for liver cancer, but the safety and thoroughness of the surgery still face many challenges. In recent years, with the in-depth development of medical-industrial interdisciplinary, digital intelligent diagnosis and treatment technologies, which are deeply formed by the integration of digital medical technology, big data and artificial intelligence, have injected new vitality into the minimally invasive surgical treatment of liver cancer, brought a brand-new perspective, and promoted the transformation of the traditional surgical paradigms into the modern minimally invasive, precise and intelligent surgical models. The authors summarize the development of digital intelligent minimally invasive surgical treatment of liver cancer over the past 20 years, discuss the evolution from clinical problems to key scientific issues, and from clinical needs to technological innovations. By reviewing past progress and looking forward to future directions, it aims to further promote the innovation of digital intelligent minimally invasive surgical techniques to improve the prognosis of patients with liver cancer.