Abstract: The incidence of intraoperative complications is high in laparoscopic esophago-jejunostomy (esophagogastrostomy), due to the unique anatomical location, confined space, and operational difficulty of the surgical procedure, especially in the radical resection of adenocarcinoma of esophagogastric junction. With the increasing maturity of laparoscopic technology, mastering the strategies of prevention and treatment of complications in laparoscopic esophagojejunostomy (esophagogastrostomy) can enhance surgical performance, reduce operation time, and minimize intraoperative and postoperative complications. Based on relevant literatures and team′s experience, the authors overview of the related complications of laparoscopic esophagojejunostomy (esophago-gastrostomy) and summarize the prevention and treatment techniques, in order to improve the success rate of the operation and reduce the incidence of surgical complications.