Abstract: Pancreatic cancer is a highly malignant cancer with low survival rate. Early diagnosis, early treatment and early recurrence intervention are the most important keys to improve overall prognosis of pancreatic cancer. With the rapid development of artificial intelligence, it is an inevitable trend to apply it to the diagnosis and treatment of pancreatic cancer to achieve precision medicine for patients. By combining with clinical data, medical images and molecular biology, artifi-cial intelligence has shown broad application prospects in the whole-process management of pancreatic cancer. The authors briefly review the application status and problems of artificial intelligence in the diagnosis and treatment of pancreatic cancer, and discuss its future development direction.