Abstract: With the large‑scale application of Helicobacter pylori (Hp) eradication therapy, the decline in the infection rate of the population will lead to a decrease in the occurrence of Hp‑related gastric cancer. In other words, the proportion of Hp‑negative gastric cancer will also increase significantly, and esophago‑gastric junction carcinoma, which is not closely related to Hp infection, will also become a new focus in the prevention and treatment of gastric cancer in the future. Image enhanced endoscopy is a type of endoscopic technique that has developed rapidly in recent years, and has played an important role in the diagnosis of early gastric cancer and esophageal cancer. However, there are still many unsolved questions about whether this technology is also valuable for esophago‑gastric junction carcinoma. The authors intend to review the current progress of image enhanced endoscopy in diagnosis and treatment of esophago-gastric junction carcinoma from the perspective of endoscopists.