Abstract: Microvascular invasion (MVI), which is defined as micro‑metastatic tumor emboli within hepatic micro‑vessels, is deemed as an indicator of biologic traits and one of the determinants of early recurrence and survival of liver and biliary tract tumors after resection. The potential role of prediction of MVI in choosing treatment strategies for patients with liver and biliary tumors has become hotspot in recent years and partly contributed to the improve the discrimination capability of clinical staging by incorporating biologic traits. The diagnosis of MVI still relies on pathological analysis of specimen obtained by resection. Recently, progress of radiological and serological tech-niques has facilitated the preoperative prediction of MVI among patients with liver and biliary tract tumors. The authors attempt to summarize the clinical management of liver and biliary tract tumors based on the decision strategies oriented by prediction of MVI in this article.