Abstract: Transplantation pathology, as an important branch of transplantation medicine, plays an important role in disease diagnosis, confirming or denying clinical diagnosis, and narrowing the scope of differential diagnosis. The Practical guidelines for the pathological diagnosis of major complications after liver transplantation (2016 edition) plays an important role in promoting the standardized development of liver transplantation pathology in China. In recent years, the research of liver transplantation pathology has been continuously deepening, and the knowledge system has been iteratively updated. In order to continuously improve the pathological diagnosis level of liver transplantation in China, under the guidance and organization of the Branch of Organ Transplant of Chinese Medical Association and other organizations, Chinese liver transplantation pathologists and clinical experts have formulated the Guidelines for pathological diagnosis of major complications after liver transplantation (2024 edition) based on domestic and foreign research and practical experience, in order to provide scientific guidance and reference for the pathological diagnosis of liver trans-plantation in China.