Abstract: Although the incidence of pancreatic cancer is increasing, due to the develop-ment of surgery, oncology and other disciplines, its prognosis has improved. The anatomical neigh-boring of pancreatic neck cancer is complex and there is no consensus in surgical decision‑making such as the extension of pancreatic resection, handling of arteriovenous invasion, and lymph node dissection, which hampered the development of safety and standardization for radical surgery. The authors review the key points of surgical decision‑making in radical surgery for pancreatic neck cancer based on evidence‑based medicine and clinical experience.