Abstract: As a mechanosensitive ion channel, Piezo1 is expressed in various immune cells and plays an important role in mediating immune response by calcium influx in response to mech-anical signals. Pancreatic parenchymal cells are highly sensitive to mechanical stress. Piezo1 can respond to mechanical stimuli during the initiation and development of pancreatitis. The authors summarize the latest research advancements on the role and molecular mechanisms of Piezo1 in various immune cells and pancreatitis in recent years and discuss the potential role of immune cell Piezo1 in acute and chronic pancreatitis, with an attempt to provide new insights for early inter-vention of pancreatitis.