Abstract: Most patients with liver malignant tumors are diagnosed as in the middle or advanced stages when first diagnosed, while the prognosis is quite poor in these stages. Early diagnosis and treatment are the key to improve the curative effect of liver malignant tumors. Recently, with the sustainable development and progress of the treatment method, the prognosis of liver malignant tumors has been greatly improved. The surgical resection is still the first‑choice in the treatment of liver malignant tumors. Precise hepatectomy is the guarantee to achieve the best surgical results, while precise preoperative assessment, intraoperative real‑time lesion localization and real‑time guidance are the priority to the precise hepatectomy. In order to improve the pre-operative diagnosis, precise intraoperative resection and postoperative curative effect of liver malignant tumors, the Hepatobiliary and Pancreatic Disease Prevention and Control Specialty Society of Chinees Prevention Medicine Association and the Hepato‑Oncology Branch of China International Exchange and Promotive Association for Medical and Healthcare organize experts to conduct in‑depth discussion on the key points of precise localization and navigation of liver tumors and formulated the Chinese Expert Consensus on Precision Guidance Technology in Diagnosis and Treatment of Liver Tumors (2024 Edition), which could guide the clinical practice and promote the development of the subject.