原发性肝癌转化及围手术期治疗中国专家共识(2024版)

Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition)

  • 摘要: 我国目前仍有超过一半的肝癌患者在初诊时即为中晚期,丧失手术切除机会,而部分可手术患者术后复发转移率高,导致患者总体生存较差。随着外科手术技术的革新、系统治疗和局部治疗手段的丰富和进步,通过多模式综合治疗策略为肿瘤转化提供可能、使患者获得手术切除机会,同时有效降低术后复发转移率,从而实现患者长期生存获益。此外,近年来研究者对转化及围手术期治疗过程中手术时机的选择、病灶评估、疗效预测、并发症处理等方面进行了进一步有益探索。在原有共识的基础上修订并更新形成《原发性肝癌转化及围手术期治疗中国专家共识(2024版)》,提出了在肝癌转化治疗和围手术期治疗领域的治疗策略和实施过程需要解决的问题,以期为推动该领域研究和临床实践奠定基础。

     

    Abstract: In China, over half of liver cancer patients are in advanced stage at initial diagno-sis, losing the opportunity for curative surgical resection, and part of resectable patients have a high postoperative recurrence rate, resulting in poor overall survival. Innovations in surgical techniques and advancements in systemic and locoregional treatments have paved the way for novel and multi-combination conversion treatment strategies. These approaches offer selected advanced liver cancer patients the prospect of tumor shrinkage and downstaging, ultimately facilitating surgical interven-tion, so as to achieve long‑term survival benefits. Furthermore, further exploration has been taken in timing of surgery, assessment of lesions, prediction of efficacy, management of complications in the context of conversion and perioperative therapy. Based on previous edition of guideline, the updated Chinese Expert Consensus on Conversion and Perioperative Therapy of Primary Liver Cancer (2024 Edition) aims to collect and summarize current clinical experience of conversion therapy and peri-operative therapy, propose remaining problems that need to be solved in conversion therapy and peri-operative therapy and provide a foundation for further research and development of liver cancer treatment in clinical practice.

     

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