Abstract: Based on the theory of surgical membrane anatomy and the abnormality of membranous structure under the condition of intra‑abdominal infection, the authors creatively propose the concept of partition of intra‑abdominal infection, and briefly explain the definition, content and significance, which has caused widespread resonance in the academic community. Combining the clinical practices and relevant literatures, several key issues related with diagnosis and therapy in the view of D region are discussed in depth, aiming at theoretical basis for scientific planning of treatment strategies and optimal system of diagnosis and treatment of intra‑abdominal infection.