Abstract: Intra‑abdominal infection is the second common infectious disease in intensive care unit and inhospital patients, with the mortality rate of 20%-30%. Advances in medicine have not improved the outcomes of patients with intra‑abdominal infection, and the increasing multi‑drug resistance organism may lead to a deterioration in the prognosis of patients with intra‑abdominal infection. Gut microbiota dysbiosis and abdominal cavity infections show an interdependent and mutually aggravating relationship. Intestinal microecological preparations regulate gut flora and are potential therapeutic measures for intra‑abdominal infections. The authors review the changes in gut flora during intra‑abdominal infection, the effect of gut flora on the prognosis of intra‑abdominal infections and the role of intestinal microecological preparations in intra‑abdominal infections.