Abstract: Liver resection is an important method for the treatment of benign and malig-nant hepatobiliary diseases. Due to severe surgical injury, complicated surgical procedures and operation difficulty, the postoperative complications are relatively more common, and infections are the frequent complications. Postoperative infection not only increases the economic burden and treatment difficulty of patients, but also affects the prognosis. There are many risk factors leading to postoperative infection. Controlling and improving these factors are effective measures to reduce or avoid postoperative infection. By reviewing the domestic and abroad literatures, and combined with the clinical experiences, the authors discuss the types of postoperative infection, the related risk factor and the corresponding prevention and treatment strategies after liver resection.