Abstract: Esophageal cancer constitutes the sixth leading cause of cancer‑associated death worldwide. Recently, due to the development of minimally invasive techniques and perioperative treatment modality, the 5‑year overall survival rate has been improved in patients with esophageal cancer undergoing esophagectomy. Therefore, long‑term quality of life (QOL) after esophagectomy in patients with esophageal cancer has attracted more and more attention. In China, unfortunately, the concern of long‑term QOL of patients after esophagectomy is absent and few QOL‑related clinical trial has been launched. The authors summarize the influencing factors for long‑term QOL after esophagectomy in patients with esophageal cancer, so as to raise more concern of long‑term QOL of patients after esophagectomy in surgeons and nurses.