Abstract: Anatomic resection aims to improve the surgical efficacy of hepatocellular carcinoma by systematic resection of portal territory. However, due to its deviation of traditional theory and practice, the oncology effect is questionable. Anatomic resection based on portal territory(PT‑AR) is planned by the analysis of real portal vein territory, and performed complete resection of tumor‑bearing portal territory by fluorescent guidance, while exposing typical inter‑territory hepatic vein, so as to ensure the complete function of future liver remnant. PT‑AR is based on the core theory of classical anatomic resection, which will correct the deviation of traditional theory and practice from the technical level, so as to lead a better surgical oncology outcomes for hepatocellular carcinoma.