Abstract: Liver is the most important metastatic target organ of colorectal cancer. Nearly 50% of colorectal patients are found to have liver metastasis during the course of the disease, including 25% of colorectal patients undergoing simultaneous liver metastasis and the other 25% undergoing metachronous liver metastasis. Liver metastasis is the main cause of death for colorectal patients and the prevention and treatment of colorectal cancer liver metastasis is the top priority to overcome the disease. Active surgical treatment can bring survival benefits to colorectal patients. The authors analyze and summarize the multidisciplinary treatment of colorectal liver metastasis in the department of organ transplantation of First Affiliated Hospital of Kunming Medical University to discuss the hepatectomy strategy of colorectal liver metastasis.