Abstract: The prevalence of overweight and obesity in China has reached the top globally, especially for children. The etiology and progression of obesity are still unknown, and the relapse of obesity after weight loss is unavoidable. Therefore, multiple interventions and combined therapy are needed to prevent the incidence and development of obesity. Nutrition therapy, activity modification, lifestyle change, psychology therapy, traditional Chinese medicine, as well as bariatric surgery are effective methods for the treatment of obesity. Current domestic or foreign consensus on obesity are only single or double disciplines guided, and focused only on nutrition or surgery. We should realize that obesity is a complex disease and should be treated over lifetime, and multidisciplinary clinical consensus should be made to exclude particular bias induced by single discipline. Thus, we invited experts in endocrinology, bariatric surgery, traditional Chinese medicine, nutrition, sports medicine, and psychology to write and revise the current multidisciplinary consensus. We hope this consensus could update and improve the diagnosis and treatment of obesity from an interdisciplinary perspective. The management of patients with obesity should be centralized and the treatment should be personalized for the improvement of individual metabolic disorders and comorbidities.