Abstract: Precise hepatobiliary surgery technical system is a full-process and full-element surgical practice norm, which is based on the value of maximizing the benefit of patients, combining various technical means as its method, with safety, high efficiency and minimal trauma as the goal. Complicated hepatolithiasis is considered as benign disease but malignant prognosis because of its disease characteristics, such as difficult preoperative evaluation, difficult operation and difficult postoperative management. The precise hepatobiliary surgery technical system plays an important role in complicated hepatolithiasis. Based on the core of diseased biliary tree clearance, surgeons have improved the certainty of preoperative assessment and surgical operations through positioning, quantitative and structure technology. The author elaborates on the core, connotation of precise hepatobiliary surgery technical system and its application in complicated hepatolithiasis.