Abstract: Liver failure is the most common clinical syndrome of severe liver diseases, and liver transplantation is the most effective treatment for liver failure. Based on evidence‑based medicine evidence obtained from researches in domestic and foreign fields, and combined with clinical practice in China, the Perioperative Management Group of Chinese Society of Organ Transplantation from Chinese Medical Association formulates the 'Chinese expert consensus on perioperative management of liver transplantation in patients with liver failure', in order to reduce the perioperative mortality of liver transplantation patients with liver failure. This consensus forms standardized contents on the preoperative evaluation, intraoperative management, and prevention and treatment of postoperative complications of liver transplantation in patients with liver failure, with the aims to enhance the level of diagnosis and treatment during the perioperative period, reduce the perioperative mortality and improve the prognosis.