Abstract: The objective research conclusions drawn from standardized clinical studies are important evidential basis for the formulation of consensus guidelines for the diagnosis and treatment of various diseases. In order to further improve the level of clinical research work and evidence quality, provide patients with more scientific treatment decision‑making opinions, the author investigate the following aspects which should be paid attention to in the clinical study of biliary tract diseases including defining the evaluation system and quality standards evidence‑based criteria for clinical studies, setting long‑term research goals, strengthening the real‑world research,"three elements"of surgical clinical research (surgical quality, pathological analysis and follow‑up), and the database construction; emphasizing the significance and implementation of quantitative analysis research, the registration system and standardized clinical research.