Abstract: The incidence of adenocarcinoma of esophagogastric junction (AEG) is on the rise. Due to its special lesion location and biological behavior, AEG is considered as a relatively independent disease by more and more scholars, which is different from esophageal cancer or gastric cancer. AEG is anatomically located at the junction of esophagus and stomach. The lymph node metastasis of AEG can be directed to the mediastinal and abdominal. At present, the rule of lymph node metastasis of AEG is not completely clear, and the scope of lymph node dissection has not reached a consensus. The authors summarize the hot issues and clinical evidence of lymph node dissection for AEG, in order to provide references for more reasonable lymph node dissection of AEG.