Abstract: Pancreatic cancer is one of the most lethal malignancies in the digestive system, and the prognosis has not been improved with the development of surgery. With the popularization of comprehensive treatment, the surgical treatment of pancreatic cancer has evolved from 'surgery first' stage to the stage of multidisciplinary collaboration in diagnosis and treatment. Great progress has been achieved in pre-operation evaluation, neoadjuvant therapy, minimally invasive surgery and post-operation adjuvant therapy of pancreatic cancer. These novel concepts and methods have improved the prognosis of patients to some extent, but controversies still exist regarding their clinical applications. It is still an important task to establish an individual, minimally invasive and precise treatment system for the surgical treatment of pancreatic cancer. The authors summarize the new progress of surgical treatment of pancreatic cancer under the concept of multiple disciplinary team in recent years, discuss the limitations and controversies, and reflect about the future development of surgical treatment of pancreatic cancer, in order to promote the development of surgical treatment of pancreatic cancer and improve the prognosis of patients.