Abstract: Radical surgical resection offers curable treatment for abdominal neoplasms involving the superior mesenteric artery (SMA). However, the combined SMA resection with reconstruction has remained a technically difficult procedure with high morbidity and mortality, which has been regarded as a surgically forbidden area. With advances in organ preservation and transplantation techniques, intestinal autotransplantation has recently emerged in clinical practice as a treatment option for neoplasms involving SMA. The operative procedure includes in vitro preservation of a segment of small intestine as the autograft, en bloc resection of the neoplasm along with involved organs, and autotransplantation of the intestine autograft. This technique has expanded eligibility for resection of otherwise unresectable lesions involving SMA. In our opinion, intestinal autotransplantation appears to be technically feasible in abdominal neoplasms encasing SMA with an acceptable morbidity and mortality. This novel technique is thus worthy of further investigation and accumulation of experience.