Abstract: Hepatolithiasis had diverse causes and complicated conditions with residual stones and recurrence after surgery,which is still a difficult point in surgical treatment. In this article, the authors focus on the timing of surgery for hepatolithiasis, preoperative imaging and precise assessment of important organs throughout the body, intraoperative technical points, progress in the application of minimally invasive techniques and endoscopic methods, surgical strategy for recurrent intrahepatic stones, application value of perihilar surgery technology and the treatment of patients combined with portal hypertension.This article aims to investigate the difficult problems that may be encountered in the surgical treatment of hepatolithiasis, improve the stone removal rate, reduce the recurrence rate, improve the patient′s prognosis and quality of life.